[Rickets resistant to calcitropic hormones].

Abstract

Resistance to vitamin D is known since a long time but was erroneously ascribed to phosphate deficiency (phosphate diabetes or deficiency in tubular phosphate reabsorption). True vitamin D resistance can either be due to lack of the receptor itself or to structural abnormality in the hormone -or DNA-binding site of the receptor whereas in a few cases post-receptor resistance has been documented. In view of the therapeutic consequences, diagnosis of vitamin D resistance is needed in every case of rickets not due to simple vitamin D deficiency. Such cases can be easily recognized by normal 25-hydroxyvitamin D concentration in the presence of biochemical, radiological or/and histological signs of rickets.

• Authors: M Vainsel, R Bouillon
• Journal: Revue medicale de Bruxelles (Rev Med Brux) Vol. 16 Issue 5 Pg. 364-7 (Nov 1995) ISSN: 0035-3639 [Print] Belgium
• Vernacular Title: Les rachitismes résistant aux hormones calciotropes.
• PMID: 7501913 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hydroxycholecalciferols
• Receptors, Calcitriol
• Vitamin D

Topics

• Drug Resistance
• Humans
• Hydroxycholecalciferols (blood)
• Hypophosphatemia, Familial (blood, metabolism)
• Receptors, Calcitriol (metabolism)
• Vitamin D (metabolism)