Alternating mitomycin C and bacillus Calmette-Guerin instillation therapy for carcinoma in situ of the bladder. The Finnbladder Group.

Abstract

PURPOSE:

Our aim was to prove if alternating chemotherapeutic and immunotherapeutic instillations improved efficacy and reduced toxicity in patients with carcinoma in situ of the bladder.

MATERIALS AND METHODS:

Of 68 carcinoma in situ patients randomly treated with instillations 40 received mitomycin C and 28 received mitomycin C and Pasteur bacillus Calmette-Guerin (BCG) in alternating courses. Mean followup was 33 months.

RESULTS:

The complete response rates with mitomycin C and mitomycin C/BCG were 45% and 71% at 3 months, 59% and 82% at 12 months, and 47% and 74% at 24 months, respectively (p = 0.041). The disease-free interval showed the superiority of alternating therapy (p = 0.043). Recurrence rates during the instillation period were 1.834 with mitomycin C and 0.922 with mitomycin C/BCG (p = 0.013). No remarkable side effects developed in the alternating group.

CONCLUSIONS:

Therapy of carcinoma in situ with alternating mitomycin C and BCG is more effective than mitomycin C alone. Compared to BCG monotherapy only few side effects occur.

• Authors: E Rintala, K Jauhiainen, P Rajala, M Ruutu, E Kaasinen, O Alfthan
• Journal: The Journal of urology (J Urol) Vol. 154 Issue 6 Pg. 2050-3 (Dec 1995) ISSN: 0022-5347 [Print] United States
• PMID: 7500456 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Antibiotics, Antineoplastic
• BCG Vaccine
• Mitomycin

Topics

• Adjuvants, Immunologic (administration & dosage)
• Administration, Intravesical
• Aged
• Antibiotics, Antineoplastic (administration & dosage)
• BCG Vaccine (administration & dosage)
• Carcinoma in Situ (therapy)
• Combined Modality Therapy
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Prospective Studies
• Urinary Bladder Neoplasms (therapy)