Abstract |
Pulmonary metastases of chinese hamster mesenchymal chondrosarcoma cell lines, MCS-1 (undifferentiated type) and MCS-8 (differentiated type), were examined by intravenous transplantation into athymic nude mice. The incidence of pulmonary metastasis of MCS-1 was 100% and that of MCS-8 was 33% at the 23rd day after transfer. Mean number of metastatic nodules in the lung was 41 in the former and only 3 in the latter. Mean survival time of mice with MCS-1 injection (5 x 10(4) cells) was 27 days and that with MCS-8 (5 x 10(4) cells) was 48 days after transfer. At the 42nd day after transfer of MCS-8, however, the incidence of pulmonary metastasis was 100%. These data suggest that the tumor growth rate in the metastatic lesion, as well as the affinity to the target organ, is very important for evaluation of experimental metastasis.
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Authors | N Fujisawa, N L Sato, T Motoyama |
Journal | Experimental animals
(Exp Anim)
Vol. 43
Issue 5
Pg. 761-4
(Oct 1995)
ISSN: 1341-1357 [Print] Japan |
PMID | 7498344
(Publication Type: English Abstract, Journal Article)
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Topics |
- Animals
- Bone Neoplasms
(pathology)
- Chondrosarcoma, Mesenchymal
(pathology, secondary)
- Cricetinae
- Cricetulus
- Female
- Lung Neoplasms
(pathology, secondary)
- Male
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Tumor Cells, Cultured
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