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Effect of prostacyclin on microvascular pressures in a patient with pulmonary veno-occlusive disease.

Abstract
Continuous-infusion prostacyclin improves symptom scores and decreases mortality in patients with primary pulmonary hypertension, but use of prostacyclin in patients with pulmonary veno-occlusive disease may precipitate pulmonary edema. A patient with pulmonary veno-occlusive disease received a graduated intravenous infusion of prostacyclin and pulmonary capillary pressures were calculated during prostacyclin dose ranging. Calculated capillary pressure increased with low-dose prostacyclin (< or = 6 ng/kg/min) but decreased with higher doses. These data suggest that the post-capillary pulmonary venules in our patient had reversible vasomotor tone, but required a higher dose of prostacyclin to vasodilate than did the precapillary arterioles.
AuthorsL L Davis, B P deBoisblanc, C E Glynn, C Ramirez, W R Summer
JournalChest (Chest) Vol. 108 Issue 6 Pg. 1754-6 (Dec 1995) ISSN: 0012-3692 [Print] United States
PMID7497799 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Platelet Aggregation Inhibitors
  • Vasodilator Agents
  • Epoprostenol
Topics
  • Blood Pressure (drug effects)
  • Epoprostenol (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Infusions, Intravenous
  • Microcirculation (drug effects, physiopathology)
  • Middle Aged
  • Platelet Aggregation Inhibitors (administration & dosage, therapeutic use)
  • Pulmonary Circulation (drug effects)
  • Pulmonary Veno-Occlusive Disease (drug therapy, physiopathology)
  • Vasodilator Agents (therapeutic use)

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