Abstract |
Evidence indicating an important link between glycosylation changes and autoimmune rheumatic disease is presented. Attention is especially focused on the interrelationship between reduced galactosylation of the oligosaccharides of IgG, auto-sensitization which is thought to be of central importance in the pathogenesis of rheumatoid arthritis (RA), and the enzyme beta 1,4-galactosyltransferase ( GTase) that catalyses the addition of galactose to the oligosaccharide chains on this molecule. Data are presented to indicate that GTase undergoes a variety of normal and disease associated changes. These variations are believed to contribute to the pathological processes in rheumatoid disease, and a hypothesis is suggested, whereby disease is associated with the dysregulation of an integrated glycosylation network, comprising IgG galactosylation, lymphocytic GTase and anti- GTase antibodies, that is a component of the normal immune system.
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Authors | A Alavi, J Axford |
Journal | Glycoconjugate journal
(Glycoconj J)
Vol. 12
Issue 3
Pg. 206-10
(Jun 1995)
ISSN: 0282-0080 [Print] United States |
PMID | 7496133
(Publication Type: Journal Article, Review)
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Chemical References |
- Isoenzymes
- N-Acetyllactosamine Synthase
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Topics |
- Arthritis, Rheumatoid
(enzymology)
- Evaluation Studies as Topic
- Glycosylation
- Humans
- Isoenzymes
(metabolism)
- N-Acetyllactosamine Synthase
(genetics, metabolism, physiology)
- Reference Values
- Regression Analysis
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