Synchronous fluctuation of interleukin-6 and platelet count in cyclic thrombocytopenia and thrombocytosis.

Abstract

We describe a case of cyclic thrombocytopenia and thrombocytosis, whose cytokine levels, granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-6 (IL-6) in plasma, fluctuated in synchrony with platelet count. The levels of the two cytokines correlated significantly with the platelet count for 11 observations over an 8-month period (r = 0.79, p < 0.01 for GM-CSF and r = 0.87, p < 0.001 for IL-6). No inverse relationship between platelet-associated immunoglobulin G (PAIgG) and platelet count was observed (r = 0.39, p > 0.20). These findings suggest that the fluctuation of platelet count in this case may result from an aberration of the cytokine network regulating megakaryopoiesis and platelet formation.

• Authors: J Kuyama, H Take, S Matsumoto, T Nakajima, T Sugase, A Hata, M Hanada, K Nakagawa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 34 Issue 7 Pg. 636-9 (Jul 1995) ISSN: 0918-2918 [Print] Japan
• PMID: 7496073 (Publication Type: Case Reports, Journal Article)

Chemical References

• Interleukin-6
• Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• Adult
• Female
• Granulocyte-Macrophage Colony-Stimulating Factor (blood)
• Humans
• Interleukin-6 (blood)
• Menstrual Cycle (blood)
• Platelet Count
• Thrombocytopenia (blood)
• Thrombocytosis (blood)