Application of ABO genotyping using polymerase chain reaction method to assess engraftment in bone marrow transplantation--a case report.

Abstract

We described a case of acute promyelocytic leukemia with O blood type who received bone marrow transplantation during a second remission from his HLA identical, B blood type sibling. Using PCR genotyping of the ABO group and analysis of the variable number of tandem repeats of the D1S80 locus, we could quickly document the successful early engraftment in this patient. We emphasize that the use of PCR ABO genotyping is a quick and valuable method which could be applied to assess the engraftment and its follow up in those transplant cases with donors of mismatched blood groups.

• Authors: C S Chang, S F Lin, J C Lee, J G Chang, T C Liu, S M Huang, T P Chen, H W Liu
• Journal: Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences (Gaoxiong Yi Xue Ke Xue Za Zhi) Vol. 11 Issue 10 Pg. 574-7 (Oct 1995) ISSN: 0257-5655 [Print] China (Republic : 1949- )
• PMID: 7494238 (Publication Type: Case Reports, Journal Article)

Chemical References

• ABO Blood-Group System

Topics

• ABO Blood-Group System (genetics)
• Adult
• Base Sequence
• Bone Marrow Transplantation
• Genotype
• Humans
• Leukemia, Promyelocytic, Acute (blood, therapy)
• Male
• Molecular Sequence Data
• Polymerase Chain Reaction