Uptake and metabolism of long-chain 1,2-diacylglycerols by rat adipocytes and H4IIE hepatoma cells.

Abstract

The physiological long-chain diacylglycerols 1,2-dioleoylglycerol and 1,2-dimyristoylglycerol were taken up and metabolized, both by adipocytes and by hepatoma cells, in amounts sufficient to elicit biological responses, without use of emulsifier or any special cell treatment. In adipocytes the only metabolic lipid product of either diacylglycerol was triacylglycerol. In hepatoma cells both diacylglycerols were converted to a number of identified products, mainly phosphatidylcholine and triacylglycerol. This has implications for the interpretation of reports in which long-chain diacylglycerols have been found ineffective in stimulation of cells.

• Authors: J Gustavsson, S Parpal, P Strålfors
• Journal: Experimental cell research (Exp Cell Res) Vol. 221 Issue 2 Pg. 443-7 (Dec 1995) ISSN: 0014-4827 [Print] United States
• PMID: 7493644 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diglycerides
• Phosphatidylcholines
• Triglycerides
• dimyristoyl diglyceride
• diolein

Topics

• Adipocytes (metabolism)
• Animals
• Biological Transport
• Cells, Cultured
• Diglycerides (metabolism)
• Liver Neoplasms, Experimental (metabolism)
• Phosphatidylcholines (biosynthesis)
• Rats
• Triglycerides (biosynthesis)
• Tumor Cells, Cultured