Abstract |
Rats were injected intraperitoneally with 0.015 mmol of p-dinitrobenzene/kg, 0.15 mmol of m-dinitrobenzene/kg and 0.45 mmol of o-dinitrobenzene/kg body wt. The dinitrobenzenes induced methaemoglobin concentrations of 86%, 60% and 49%, respectively, as well as increases of urinary catecholamine excretion and blood sugar concentration. Due to hyperglycaemia the glycolysis may be stimulated as mechanism for energy production in methaemoglobin-induced oxygen deficiency and as mechanism for reduction of methaemoglobin, that means as responses favouring survival after poisoning.
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Authors | D Pankow, W Ponsold |
Journal | Toxicology
(Toxicology)
Vol. 11
Issue 4
Pg. 377-83
(Dec 1978)
ISSN: 0300-483X [Print] Ireland |
PMID | 749274
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Catecholamines
- Dinitrobenzenes
- Nitrobenzenes
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Catecholamines
(urine)
- Dinitrobenzenes
(administration & dosage, poisoning)
- Fasting
- Injections, Intraperitoneal
- Male
- Methemoglobinemia
(chemically induced)
- Nitrobenzenes
(poisoning)
- Rats
- Structure-Activity Relationship
- Time Factors
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