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Urinary catecholamine excretion and blood sugar response during acute poisonings with dinitrobenzenes.

Abstract
Rats were injected intraperitoneally with 0.015 mmol of p-dinitrobenzene/kg, 0.15 mmol of m-dinitrobenzene/kg and 0.45 mmol of o-dinitrobenzene/kg body wt. The dinitrobenzenes induced methaemoglobin concentrations of 86%, 60% and 49%, respectively, as well as increases of urinary catecholamine excretion and blood sugar concentration. Due to hyperglycaemia the glycolysis may be stimulated as mechanism for energy production in methaemoglobin-induced oxygen deficiency and as mechanism for reduction of methaemoglobin, that means as responses favouring survival after poisoning.
AuthorsD Pankow, W Ponsold
JournalToxicology (Toxicology) Vol. 11 Issue 4 Pg. 377-83 (Dec 1978) ISSN: 0300-483X [Print] Ireland
PMID749274 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Catecholamines
  • Dinitrobenzenes
  • Nitrobenzenes
Topics
  • Animals
  • Blood Glucose (metabolism)
  • Catecholamines (urine)
  • Dinitrobenzenes (administration & dosage, poisoning)
  • Fasting
  • Injections, Intraperitoneal
  • Male
  • Methemoglobinemia (chemically induced)
  • Nitrobenzenes (poisoning)
  • Rats
  • Structure-Activity Relationship
  • Time Factors

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