Growth hormone deficiency and empty sella in DIDMOAD syndrome: an endocrine study.

Abstract

Two girls with DIDMOAD syndrome are presented. One also had severe megaloblastic-sideroblastic anaemia and the other several neurological manifestations. Both were short with defective growth hormone secretion. Computed tomography revealed empty sella in both girls; one had widespread atrophic cortical and cerebellar changes. High doses of thiamine improved the anaemia in the first case, increased C peptide secretion in both, but had no effect on the neurological abnormalities.

• Authors: A T Soliman, B Bappal, A Darwish, A Rajab, M Asfour
• Journal: Archives of disease in childhood (Arch Dis Child) Vol. 73 Issue 3 Pg. 251-3 (Sep 1995) ISSN: 1468-2044 [Electronic] England
• PMID: 7492167 (Publication Type: Case Reports, Journal Article)

Chemical References

• C-Peptide
• Growth Hormone
• Thiamine

Topics

• Anemia, Sideroblastic (drug therapy)
• C-Peptide (metabolism)
• Empty Sella Syndrome (complications, diagnostic imaging)
• Female
• Growth Hormone (deficiency)
• Humans
• Infant
• Nervous System Diseases (complications)
• Thiamine (therapeutic use)
• Tomography, X-Ray Computed
• Wolfram Syndrome (complications, metabolism)