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Cathepsin D in normal and neoplastic thyroid tissues.

AbstractBACKGROUND:
Cathepsin D is a widely distributed lysosomal acidic endopeptidase. It is an estrogen-regulated protein that is a prognostic factor in breast cancer. The aim of this study was to measure cathepsin D concentrations in thyroid tissues and to correlate these concentrations with clinical and pathologic parameters.
METHODS:
Cathepsin D and thyroglobulin concentrations were measured in the cytosol of normal thyroid tissues (n = 14), benign nodules (n = 6), and thyroid carcinomas (n = 32) with an immunoradiometric assay. Statistical analysis was based on the Kruskal-Wallis and Wilcoxon tests and on the Spearman rank correlation coefficient.
RESULTS:
The mean level of cathepsin D, expressed as picomoles per milligram protein minus thyroglobulin, was higher in the 32 carcinomas, 29.1 +/- 15.5, than in the 14 normal thyroid tissues, 8.4 +/- 2.5 (p < 0.001) or in the 6 benign nodules, 11.2 +/- 7.3 (p = 0.003). Cathepsin D concentrations correlated with tumor size; Spearman rank correlation coefficient was rs = 0.44 (p = 0.012). No significant difference was found regarding histologic type. Cathepsin D concentrations were inversely correlated with the thyroglobulin level in the tumor; Spearman rank correlation coefficient was rs = -0.60 (p < 0.001).
CONCLUSIONS:
Cathepsin D concentration is higher in thyroid carcinoma than in normal thyroid tissue. Increased cathepsin D concentrations correlate with thyroid tumor size but not with histologic type. Further studies should be done to confirm the potential prognostic value of cathepsin D in patients with thyroid carcinomas.
AuthorsJ L Kraimps, T Métayé, C Millet, D Margerit, P Ingrand, J M Goujon, P Levillain, P Babin, F Begon, J Barbier
JournalSurgery (Surgery) Vol. 118 Issue 6 Pg. 1036-40 (Dec 1995) ISSN: 0039-6060 [Print] UNITED STATES
PMID7491520 (Publication Type: Journal Article)
Chemical References
  • Thyroglobulin
  • Cathepsin D
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Cathepsin D (analysis)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reference Values
  • Thyroglobulin (analysis)
  • Thyroid Gland (chemistry)
  • Thyroid Neoplasms (chemistry, pathology)

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