[DNA polymorphism of the BoLA-DRB3 gene in cattle in connection with resistance and susceptibility to leukemia].

Abstract

Polymorphism of exon 2 of the BoLA-DRB3 gene was investigated by the PCR-RFLP method in a sample of healthy and leukemia-afflicted Black Pied cattle. Allele variety was studied and allele frequencies were determined in a total sample and in the two groups. Alleles mediating resistance (BoLA-DRB3.2*11, *23, and *28) and susceptibility to leukemia (DRB3.2*22, *24, *16, and *8) were revealed in Black Pied cattle. The dominant type of inheritance of the disease resistance was confirmed. On the basis of original and published data obtained earlier for Holstein-Friesian cattle, a conclusion was made about the universal character of the spectrum of BoLA-DRB3 alleles providing resistance and susceptibility to leukemia.

• Authors: G E Sulimova, I G Udina, G O Shaĭkhaev, I A Zakharov
• Journal: Genetika (Genetika) Vol. 31 Issue 9 Pg. 1294-9 (Sep 1995) ISSN: 0016-6758 [Print] Russia (Federation)
• Vernacular Title: DNK-polimorfizm gena BoLa-DRB3 u krupnogo rogatogo skota v sviazi s ustoĭchivost'iu i vospriimchivost'iu k leĭkozu.
• PMID: 7489890 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA Primers
• Histocompatibility Antigens
• DNA

Topics

• Alleles
• Animals
• Base Sequence
• Cattle (genetics, immunology)
• DNA
• DNA Primers
• Enzootic Bovine Leukosis (genetics, immunology)
• Exons
• Gene Amplification
• Gene Frequency
• Genetic Predisposition to Disease
• Histocompatibility Antigens (genetics)
• Molecular Sequence Data
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Restriction Mapping