Mortality, endotoxaemia and cytokine expression after intermittent and continuous hepatic ischaemia.

Abstract

This study compared mortality rates, endotoxaemia, systemic tumour necrosis factor (TNF) and interleukin (IL)-6 concentrations after continuous and intermittent hepatic ischaemia. Two groups of rats were subjected to continuous or intermittent left hepatic inflow occlusion for a total period of 120 min in each group. Intermittent ischaemia was associated with significantly lower mortality rates than continuous ischaemia (four of 20 versus 15 of 20; P = 0.0015). In a separate study, again following 120 min continuous or intermittent ischaemia, systemic blood was sampled at 0 min, 1 h, 3 h and 5 h after final clamp release for measurement of endotoxin, TNF and IL-6 concentrations. Endotoxin concentrations were significantly lower at 1 h, as were TNF and IL-6 concentrations at 3 and 5 h, after final clamp release in the group having intermittent ischaemia (P < 0.05). Intermittent ischaemia is associated therefore with significantly reduced mortality rates and lower systemic endotoxin, TNF and IL-6 concentrations when compared with continuous ischaemia.

• Authors: G Hewitt, I Halliday, M McCaigue, G Campbell, B Rowlands, T Diamond
• Journal: The British journal of surgery (Br J Surg) Vol. 82 Issue 10 Pg. 1424-6 (Oct 1995) ISSN: 0007-1323 [Print] England
• PMID: 7489185 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endotoxins
• Interleukin-6
• Interleukins
• Tumor Necrosis Factor-alpha

Topics

• Animals
• Endotoxins (blood)
• Enzyme-Linked Immunosorbent Assay
• Interleukin-6 (metabolism)
• Interleukins (metabolism)
• Ischemia
• Liver (blood supply)
• Male
• Rats
• Rats, Sprague-Dawley
• Time Factors
• Tumor Necrosis Factor-alpha (metabolism)