| Abstract | This study compared mortality rates, endotoxaemia, systemic tumour necrosis factor (TNF) and interleukin (IL)-6 concentrations after continuous and intermittent hepatic ischaemia. Two groups of rats were subjected to continuous or intermittent left hepatic inflow occlusion for a total period of 120 min in each group. Intermittent ischaemia was associated with significantly lower mortality rates than continuous ischaemia (four of 20 versus 15 of 20; P = 0.0015). In a separate study, again following 120 min continuous or intermittent ischaemia, systemic blood was sampled at 0 min, 1 h, 3 h and 5 h after final clamp release for measurement of endotoxin, TNF and IL-6 concentrations. Endotoxin concentrations were significantly lower at 1 h, as were TNF and IL-6 concentrations at 3 and 5 h, after final clamp release in the group having intermittent ischaemia (P < 0.05). Intermittent ischaemia is associated therefore with significantly reduced mortality rates and lower systemic endotoxin, TNF and IL-6 concentrations when compared with continuous ischaemia. |
| Authors | G Hewitt, I Halliday, M McCaigue, G Campbell, B Rowlands, T Diamond
(Affiliation: Department of Surgery, Queen's University of Belfast, UK.)
|
| Journal | The British journal of surgery
(Br J Surg)
Vol. 82
Issue 10
Pg. 1424-6
(Oct 1995)
ISSN: 0007-1323 ENGLAND |
| PMID | 7489185
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Endotoxins
- Interleukin-6
- Interleukins
- Tumor Necrosis Factor-alpha
|
| Topics |
- Animals
- Endotoxins
(blood)
- Enzyme-Linked Immunosorbent Assay
- Interleukin-6
(metabolism)
- Interleukins
(metabolism)
- Ischemia
- Liver
(blood supply)
- Male
- Rats
- Rats, Sprague-Dawley
- Time Factors
- Tumor Necrosis Factor-alpha
(metabolism)
|
