Effect of isocarbacyclin methyl ester incorporated in lipid microspheres on experimental models of peripheral obstructive disease.

Abstract

The effect of TTC-909 (isocarbacyclin methyl ester (CAS 88931-51-5, TEI-9090) incorporated into lipid microspheres) on obstruction of the peripheral artery was studied in two different animal models. The first was a peripheral occlusion model induced by intra-arterial injection of sodium laurate in rats. The second was a tail gangrene model induced by subcutaneous injection of both ergotamine and epinephrine in rats. Intravenous bolus-administered TTC-909 at 1.0 microgram/kg resulted in the inhibition of both progression of lesions induced by sodium laurate and the extension of tail gangrene by ergotamine and epinephrine. Moreover, the inhibitory effect of TTC-909 was more potent than that of PGE1 (LM) (prostaglandin E1 incorporated into lipid microspheres). These findings suggested that TTC-909 may be clinically useful for the therapy of peripheral vascular disorders such as thromboangiitis obliterans (TAO) and atherosclerosis obliterans (ASO).

• Authors: T Murakami, K Sawada, K Taneda, M Hayashi, Y Katsuura, H Tanabe, M Kiyoki, H Araki
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 45 Issue 9 Pg. 991-4 (Sep 1995) ISSN: 0004-4172 [Print] Germany
• PMID: 7488320 (Publication Type: Journal Article)

Chemical References

• Drug Carriers
• Lauric Acids
• Liposomes
• TTC 909
• Vasodilator Agents
• Epoprostenol
• Alprostadil
• Ergotamine
• Epinephrine

Topics

• Alprostadil (administration & dosage, therapeutic use)
• Animals
• Drug Carriers
• Epinephrine
• Epoprostenol (administration & dosage, analogs & derivatives, therapeutic use)
• Ergotamine
• Gangrene (chemically induced, drug therapy, pathology)
• Lauric Acids
• Liposomes
• Male
• Peripheral Vascular Diseases (chemically induced, drug therapy, pathology)
• Rats
• Rats, Wistar
• Tail (pathology)
• Vasodilator Agents (administration & dosage, therapeutic use)