A prostaglandin synthesis inhibitor, diclofenac sodium in the treatment of primary nocturnal enuresis.

Abstract

Various treatment modalities have been used in Primary Nocturnal Enuresis (PNE) and pharmacotherapy is widely accepted. Prostaglandins increase detrusor pressure, decrease urethral pressure and lead to sodium excretion. They also antagonize hydro-osmotic effect of vasopressin by competing with this hormone. According to these functions of prostaglandins it is suggested that inhibition of prostaglandin synthesis may have value in the management of PNE. We evaluated the efficacy or oral diclofenac sodium treatment in 78 patients. We conclude that diclofenac sodium, an inhibitor of prostaglandin synthesis, is a good alternative agent for nocturnal enuresis particularly as a supplementary treatment combined to Imipramine, with 60% complete response and 13.3% recurrence rate.

• Authors: E Batislam, B Nuhoğlu, L Peşkircioğlu, L Emir, C Uygur, C Germiyanoğlu, D Erol
• Journal: Acta urologica Belgica (Acta Urol Belg) Vol. 63 Issue 3 Pg. 35-8 (Sep 1995) ISSN: 0001-7183 [Print] Belgium
• PMID: 7484520 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Cyclooxygenase Inhibitors
• Diclofenac

Topics

• Adolescent
• Child
• Cyclooxygenase Inhibitors (therapeutic use)
• Diclofenac (therapeutic use)
• Enuresis (drug therapy)
• Female
• Humans
• Male
• Recurrence