[Evaluation of the effectiveness of the preparation Panzytrat 20,000 U in the substitute treatment of chronic pancreatitis].

Abstract

Panzytrat 20,000 U produced by Knoll is a modern galenic form of active pancreatic enzymes in the form of microgranules with uniform enzymatic composition. The studies of the preparation effectiveness were carried out in 88 patients with diagnosed exocrine failure in the course of chronic pancreatitis. The patients were taking Panzytrat 20,000 for 4 weeks in doses 3 x 1 capsule with main meals. Control examinations were performed two and four weeks after starting the treatment, assessing the patients' condition on the basis of history taking and medical examination; taking into account weight gain, duration and intensity of pain and dyspeptic symptoms, frequency and character of defeacations and possible undesirable effects. In a group of 37 patients, BNT-PABA test was also performed before the treatment and after one capsule of Panzytrat. The treatment with Panzytrat 20,000 caused a statistically significant reduction of the number of defecations, significant reduction of pain and dyspeptic symptoms. A statistically significant increase of PABA recovery in urine was also obtained after one capsule of the preparation. Practically, no unfavourable effects of the treatment were observed. The studies carried out point to the high effectiveness of Panzytrat in dose 3 x 20,000. U daily in the treatment of exocrine pancreatic failure in the course of chronic pancreatitis.

• Authors: G Rydzewska, E Turecka-Kulesza, J Ciok, J Pietrzak, A Gabryelewicz, E Butruk, J Dzieniszewski
• Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) (Wiad Lek) Vol. 47 Issue 19-20 Pg. 738-44 (Oct 1994) ISSN: 0043-5147 [Print] Poland
• Vernacular Title: Ocena skuteczności preparatu Panzytrat 20,000 j w leczeniu substytucyjnym przewlekłego zapalenia trzustki.
• PMID: 7483619 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Gastrointestinal Agents
• Pancreatin
• 4-Aminobenzoic Acid

Topics

• 4-Aminobenzoic Acid (urine)
• Adolescent
• Adult
• Chronic Disease
• Drug Administration Schedule
• Female
• Gastrointestinal Agents (therapeutic use)
• Humans
• Male
• Middle Aged
• Pancreatin (therapeutic use)
• Pancreatitis (drug therapy, urine)
• Treatment Outcome