Abstract |
Paraneoplastic encephalomyelitis/paraneoplastic sensory neuronopathy (PEM/PSN) associated with small cell lung cancer is characterized by high serum and CSF titers of anti-neuronal (anti-Hu) antibodies and by intrathecal synthesis of anti-Hu IgG. A pathologic role for the anti-Hu antibodies in PEM/PSN is further suggested by reported intraneuronal accumulation of the antibodies in the nervous system of PEM/PSN patients at autopsy. We immunized SJL/J mice, Lewis rats, and Hartley guinea pigs with purified recombinant HuD fusion protein. In spite of high-titer anti-HuD antibodies, neurologic and pathologic examination of the animals was normal. Apparent uptake of purified IgG by neurons in the brain proved to be artifactual.
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Authors | P A Sillevis Smitt, G T Manley, J B Posner |
Journal | Neurology
(Neurology)
Vol. 45
Issue 10
Pg. 1873-8
(Oct 1995)
ISSN: 0028-3878 [Print] United States |
PMID | 7477985
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies
- ELAV Proteins
- ELAV-Like Protein 4
- ELAVL4 protein, human
- Elavl4 protein, mouse
- Nerve Tissue Proteins
- RNA-Binding Proteins
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Topics |
- Animals
- Antibodies
(administration & dosage)
- Antibody Formation
- Base Sequence
- Brain
(pathology)
- ELAV Proteins
- ELAV-Like Protein 4
- Encephalomyelitis
(immunology, pathology)
- Guinea Pigs
- Humans
- Immunization
- Immunohistochemistry
- Mice
- Molecular Sequence Data
- Nerve Tissue Proteins
- Paraneoplastic Syndromes
(immunology, pathology)
- RNA-Binding Proteins
(administration & dosage, immunology)
- Rats
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