HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Neurodegeneration in the limbic and paralimbic system in progressive supranuclear palsy.

Abstract
Progressive supranuclear palsy is neuropathologically characterized by neuronal degeneration of the basal ganglia, brain stem, and cerebellum. In addition, cortical neuronal degeneration associated with neurofibrillary tangles formation has been identified over wide areas of the brain in patients with progressive supranuclear palsy. We studied the distribution of alpha B-crystallin-positive degenerating neurons in cases with progressive supranuclear palsy, and compared them with those in Pick's disease. Alzheimer's disease, senile dementia of Alzheimer type, and normal aged individuals. A large number of alpha B-crystallin-positive neurons was found in the cerebral cortices of four out of nine patients with progressive supranuclear palsy. In particular, alpha B-crystallin-positive ballooned neurons were frequently observed in deep cortical pyramidal cell layers of the limbic and paralimbic systems in these diseases. The involvement of the limbic and paralimbic systems may thus contribute to personality changes as well as to memory and cognitive impairment in some patients with progressive supranuclear palsy.
AuthorsY Higuchi, T Iwaki, J Tateishi
JournalNeuropathology and applied neurobiology (Neuropathol Appl Neurobiol) Vol. 21 Issue 3 Pg. 246-54 (Jun 1995) ISSN: 0305-1846 [Print] England
PMID7477733 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Immune Sera
Topics
  • Aged
  • Alzheimer Disease (pathology)
  • Cerebral Palsy (pathology)
  • Dementia (diagnosis, pathology)
  • Female
  • Humans
  • Immune Sera (immunology)
  • Immunohistochemistry
  • Limbic System (pathology)
  • Male
  • Middle Aged
  • Nerve Degeneration

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: