Myelofibrosis with complex chromosome abnormality in a patient with erythrocytosis due to hemoglobin Rainier and treated with 32P.

Abstract

A patient with familial erythrocytosis associated with Hemoglobin Rainier, and previously treated with 32P, developed myelofibrosis with a hyperdiploid chromosome clone in the myeloid cells (51,XX,+1,2q-(q33),+6,+9,+11,-19,+20q+,+mar 1.) This transformation from a benign disorder of differentiated erythrocytes to a malignant disorder may have been secondary to radiophosphorus therapy.

• Authors: V Najfeld, T H Price, J W Adamson, P J Fialkow
• Journal: American journal of hematology (Am J Hematol) Vol. 5 Issue 1 Pg. 63-9 ( 1978) ISSN: 0361-8609 [Print] United States
• PMID: 747183 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hemoglobins, Abnormal
• Phosphorus Radioisotopes

Topics

• Chromosome Aberrations (blood)
• Chromosome Disorders
• Female
• Hemoglobins, Abnormal
• Humans
• Karyotyping
• Middle Aged
• Phosphorus Radioisotopes (therapeutic use)
• Polycythemia (blood, complications, genetics, therapy)
• Primary Myelofibrosis (blood, complications, genetics)
• Washington