Distribution of HLA antigens in patients with Ewing's sarcoma.

Abstract

Thirty-eight unrelated Caucasian patients with Ewing's sarcoma were typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with local controls, a trend towards increases in LHA-B8 and Aw19 complex antigens was noted. Although American blacks are only rarely affected by this tumor, the two black patients we typed both had the HLA-Aw19 complex antigen, Aw31. This suggests that a disease susceptibility factor may be in linkage disequilibrium with HLA-Aw19 complex HLA antigens.

• Authors: K W Chan, G Rosen, M S Pollack
• Journal: Tissue antigens (Tissue Antigens) Vol. 16 Issue 4 Pg. 314-6 (Oct 1980) ISSN: 0001-2815 [Print] England
• PMID: 7466790 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA Antigens

Topics

• Adolescent
• Adult
• Child
• Genetic Linkage
• HLA Antigens (genetics, immunology)
• Humans
• Sarcoma, Ewing (genetics, immunology)