Parameters of humoral and cellular immunity of influenza A/USSR/90/77 (H1N1) virus in various age groups.

Abstract

After a local epidemic of A/USSR influenza, immunologic parameters related to influenza A/USSR/90/77 (H1N1) virus were studied in four age groups: elderly persons (greater than or equal to 64 years), healthy adults (20-44 years), children (six to 13 years), and neonates (who served as controls). Sera from the first three groups had nearly equivalent titers of hemagglutination-inhibiting antibody (geometric mean titers, 1:8-1:11), which were greater than those in cord blood of neonates. Lymphocyte proliferation responses to influenza A/USSR viral antigens among study groups were similar, with mean stimulation ratios (to whole virus) of 4.2-5.4; neonatal cord blood samples were unresponsive (stimulation ratio, 1.1). In contrast, the magnitude of antibody-dependent cellular cytotoxicity against baby hamster kidney target cells infected with influenza A/USSR virus was significantly greater with lymphocytes from adults and elderly persons (P less than 0.05) than with those from children.

• Authors: F L Ruben, H Bachmayer, P Fireman
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 142 Issue 5 Pg. 699-703 (Nov 1980) ISSN: 0022-1899 [Print] United States
• PMID: 7462685 (Publication Type: Journal Article)

Chemical References

• Antigens, Viral

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Antibody Formation
• Antigens, Viral (immunology)
• Child
• Cytotoxicity Tests, Immunologic
• Humans
• Immunity, Cellular
• Influenza A Virus, H1N1 Subtype
• Influenza A virus (immunology)
• Lymphocyte Activation
• Lymphocytes (immunology, physiology)
• Middle Aged