Inhibition of experimental bladder tumor induction by systemic BCG treatment.

Abstract

Transitional cell carcinoma of the urinary bladder was induced in rats by ingestion of 0.188% N-[4-5-nitro-2-furyl)-2-thiazolyl] formamide. During the induction period of 8 months, one animal group received systemic BCG treatment. After 12 months, the BCG-treated rats showed a significantly lower bladder tumor weight and stage than the corresponding controls. The results are discussed with regard to the possibility of BCG prophylaxis of human bladder tumors.

• Authors: H D Adolphs, J Thiele, H Kiel
• Journal: European urology (Eur Urol) Vol. 7 Issue 1 Pg. 35-8 ( 1981) ISSN: 0302-2838 [Print] Switzerland
• PMID: 7460994 (Publication Type: Journal Article)

Chemical References

• BCG Vaccine

Topics

• Animals
• BCG Vaccine (therapeutic use)
• Body Weight
• Carcinoma, Transitional Cell (pathology, prevention & control)
• Female
• Kidney Pelvis (pathology)
• Neoplasm Staging
• Neoplasms, Experimental (pathology, prevention & control)
• Organ Size
• Rats
• Urinary Bladder Neoplasms (pathology, prevention & control)