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Neonatal rickets. Histopathology and quantitative bone changes.

Abstract
Ribs from 3 preterm infants, who had died after prolonged intravenous feeding and artificial ventilation, were examined histologically and assessed for the degree of osteomalacia and osteoporosis in cancellous bone of the shaft. A grid counting technique was used. Osteomalacia was noted in all 3 cases but to a lesser degree than in classical vitamin D-deficient controls. Osteoporosis was pronounced in the cases of neonatal rickets, but this was not a feature of the vitamin D-deficient controls. Histological features were similar to those reported in experimental phosphate-deficient rickets and vitamin D-resistant rickets.
AuthorsS J Oppenheimer, G J Snodgrass
JournalArchives of disease in childhood (Arch Dis Child) Vol. 55 Issue 12 Pg. 945-9 (Dec 1980) ISSN: 1468-2044 [Electronic] England
PMID7458393 (Publication Type: Case Reports, Comparative Study, Journal Article)
Topics
  • Bone and Bones (pathology)
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases (pathology)
  • Osteomalacia (pathology)
  • Osteoporosis (pathology)
  • Rickets (pathology)

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