Therapy of mouse lymphoma with monoclonal antibodies to glycolipid: selection of low antigenic variants in vivo.

Abstract

Growth of mouse lymphoma L5178Y, which contains large quantitites of the gangliotriosylceramide (GgOs3Cer), in DBA/2 mice was suppressed by passive immunization with monoclonal immunoglobulin G3 antibodies to GgOS3Cer, but not by immunoglobulin M antibodies with or without added complement. Most groups of mice treated with monoclonal immunoglobulin G3 antibodies did not develop tumors, but the tumor that appeared in a treated animal had a much lower amount of the GgOS3Cer than the cells used for inoculation. Thus, passive immunization either prevented growth of the lymphoma or caused selection of a variant with a lower quantity of the antigen GgOS3Cer.

• Authors: W W Young Jr, S I Hakomori
• Journal: Science (New York, N.Y.) (Science) Vol. 211 Issue 4481 Pg. 487-9 (Jan 30 1981) ISSN: 0036-8075 [Print] United States
• PMID: 7455688 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Neoplasm
• Antigens, Surface
• Glycolipids
• Immunoglobulin G
• Immunoglobulin M

Topics

• Animals
• Antigens, Neoplasm
• Antigens, Surface
• Clone Cells (immunology)
• Glycolipids (immunology)
• Hybrid Cells (immunology)
• Immunization, Passive
• Immunoglobulin G (administration & dosage)
• Immunoglobulin M (administration & dosage)
• Immunotherapy
• Lymphoma (immunology, therapy)
• Mice
• Neoplasms, Experimental (therapy)