Recent results with clinically used antineoplastic drugs and drug combinations in vivo.

Abstract

Using four mouse tumor systems--leukemia L1210, i.m. mammary carcinoma 1142A, Lewis lung carcinoma, metastatic model of the mammary carcinoma 1142A--a combined treatment consisting of vincristine--cyclophosphamide--metrotrexate--5-fluorouracil is superior to a combined treatment with carminomycin--dibromodulcitol. The treatment with carminomycin and dibromodulcitol in each case alone causes therapeutic benefits being superior to a treatment with the combination carminomycin--dibromodulcitol. This result could be stated for all tumor systems used. Carminomycin showed the greatest effectivity against the leukemia L1210. A human tumor nude mouse system--ascitic mesothelioma 1503A--is presented which is suitable for chemotherapeutic experiments. First test results indicated an antineoplastic effectivity after daunoblastin treatment, but cyclophosphamide and carminomycin did not influence the life span.

• Authors: W Arnold, S Tanneberger, C Nowak, H Naundorf
• Journal: Oncology (Oncology) Vol. 37 Suppl 1 Pg. 34-41 ( 1980) ISSN: 0030-2414 [Print] Switzerland
• PMID: 7454199 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Animals
• Antineoplastic Agents (administration & dosage)
• Drug Therapy, Combination
• Humans
• Leukemia L1210 (drug therapy)
• Lung Neoplasms (drug therapy)
• Mammary Neoplasms, Experimental (drug therapy)
• Mesothelioma (drug therapy)
• Mice
• Mice, Nude
• Models, Biological
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Transplantation, Heterologous