PS-6 and PS-7, new beta-lactam antibiotics. In vitro and in vivo evaluation.

Abstract

Biological properties of two new beta-lactam antibiotics, PS-6 and PS-7, containing the carbapenem nucleus were studied. The in vitro activities of PS-6 and PS-7 were tested against clinical isolates of Gram-positive and Gram-negative bacteria in comparison with those of cefazolin, ampicillin and PS-5. In general, the antibacterial spectra of PS-6 and PS-7 were similar to that of PS-5. PS-7 was slightly less active than PS-5 and ABPC against Staphylococcus aureus. Clinical isolates of Gram-negative bacteria were found to be 2- to 8-fold more resistant to PS-6 than to PS-5, while PS-7 was 2-fold more active than PS-5 against Enterobacter, Klebsiella, Proteus, Serratia and Escherichia coli. The therapeutic effect of PS-6 seemed slightly less than that of PS-5 in an experimental infection with Staph. aureus Smith in mice.

• Authors: M Sakamoto, N Shibamoto, H Iguchi, K Okamura, S Hori, Y Fukagawa, T Ishikura, J Lein
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 33 Issue 10 Pg. 1138-45 (Oct 1980) ISSN: 0021-8820 [Print] England
• PMID: 7451364 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Thienamycins
• beta-Lactams
• antibiotic PS 7
• antibiotic PS 6
• Ampicillin
• Cefazolin

Topics

• Ampicillin (pharmacology)
• Animals
• Anti-Bacterial Agents (blood, pharmacology, therapeutic use)
• Bacteria (drug effects)
• Cefazolin (pharmacology)
• Male
• Mice
• Microbial Sensitivity Tests
• Staphylococcal Infections (drug therapy)
• Thienamycins
• beta-Lactams (blood, pharmacology, therapeutic use)