BBM-928, a new antitumor antibiotic complex. I. Production, isolation, characterization and antitumor activity.

Abstract

A complex of the antitumor antibiotic BBM-928 was produced by an actinomycete strain No. G455-101. Four components, BBM-928 A, B, C and D, were isolated in crystalline form and characterized. They were shown to be cyclic depsipeptide antibiotics containing a quinoline nucleus as the chromophore. BBM-928 A is a monoacetyl derivative of BBM-928 B and a diacetyl derivative of BBM-928 C. BBM-928 components exhibit antimicrobial activity against Gram-positive and acid-fast bacteria. BBM-928 A is highly active in mice against various experimental tumors including leukemia P388, leukemia L1210, melanoma B16, LEWIS lung carcinoma and sarcoma 180. BBM-928 B is less active than BBM-928 A, and BBM-928 C has no antitumor activity.

• Authors: H Ohkuma, F Sakai, Y Nishiyama, M Ohbayashi, H Imanishi, M Konishi, T Miyaki, H Koshiyama, H Kawaguchi
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 33 Issue 10 Pg. 1087-97 (Oct 1980) ISSN: 0021-8820 [Print] England
• PMID: 7451357 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Quinolines
• BBM-928 D
• BBM-928

Topics

• Animals
• Antibiotics, Antineoplastic (biosynthesis, isolation & purification, pharmacology)
• Bacteria (drug effects)
• Chemical Phenomena
• Chemistry, Physical
• Fermentation
• Lethal Dose 50
• Leukemia P388 (drug therapy)
• Mice
• Quinolines (biosynthesis, isolation & purification, pharmacology)