Comparison of experimental and spontaneous bladder urothelial hyperplasias occurring in BALB/c mice.

Abstract

Spontaneously occurring hyperplasia of urothelium of mice was compared morphologically to hyperplasia induced with 2-acetylaminofluorene (2-AAF) and 4-ethylsulfonylnaphthalene-1-sulfonamide (ENS). Simple and nodular hyperplasias were seen in all groups. Nodular downward hyperplasia was more commonly located in the vertex of the bladder of the 2-AAF treated mice but was more commonly located in the neck region of the ENS and control mice. The 2-AAF induced hyperplasia appeared to be capable of regression or progression to neoplasia. The ENS induced and the spontaneously occurring downward hyperplasia appeared to be secondary to a chronic cystitis and did not appear to progress to neoplasia.

• Authors: Y Shinohara, C H Frith
• Journal: Investigative urology (Invest Urol) Vol. 18 Issue 4 Pg. 235-8 (Jan 1981) ISSN: 0021-0005 [Print] United States
• PMID: 7451083 (Publication Type: Comparative Study, Journal Article)

Topics

• Animals
• Cystitis (complications, pathology)
• Hyperplasia
• Mice
• Urinary Bladder (pathology)