[Prevention of the unwanted action of hydrocortisone on the growth and development of rat pups with cholinolytic preparations].

Abstract

Experiments on young rats have shown that diplacin and d-tubocurarine in doses amounting to 1/15-1/20 of LD50 lower the ability of hydrocortisone to interfere with the physical development of the animals. Metamisyl, metacin, gangleron and benzohexonium have no such properties. In adult rats and guinea-pigs, diplacin exerts no effect on the intensity of anti-inflammatory and antiallergic action of the hormonal drug, while d-tubocurarine diminishes the anti-inflammatory effect of the corticosteroid in experimental formalin-induced paw edema and weakens its effect on the immediate type hypersensitivity.

• Authors: M V Nezhentsev
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1980 Nov-Dec Vol. 43 Issue 6 Pg. 720-4 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Preduprezhdenie kholinoliticheskimi preparatami nezhelatel'nogo deĭstviia gidrokortizona na rost i razvitie krysiat.
• PMID: 7450013 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Muscle Relaxants, Central
• Parasympatholytics
• Hydrocortisone

Topics

• Animals
• Anti-Inflammatory Agents
• Body Weight (drug effects)
• Drug Interactions
• Growth (drug effects)
• Guinea Pigs
• Hydrocortisone (adverse effects, antagonists & inhibitors)
• Hypersensitivity (drug therapy)
• Male
• Muscle Relaxants, Central (pharmacology)
• Parasympatholytics (pharmacology)
• Rats
• Time Factors