[Stimulating action of estradiol dipropionate on uterine sarcomagenesis induced by 1,2-dimethylhydrazine in mice].

Abstract

CBA female mice received weekly subcutaneous injections of 1,2-dimethylhydrazine (1,2-DMH) in a dose of 8 mg/kg for 10 weeks (group 1). In groups 2,3 and 4 1,2-DMH plus estradiol dipropionate were administered for 10, 20 or 25 weeks, respectively. The incidence of uterine sarcoma in groups 1, 2, 3 and 4 was 3.3, 2.5, 65.4 and 73%, respectively. The mice given estradiol dipropionate alone developed no uterine sarcomas. Possible mechanisms of the uterine sarcomogenesis stimulation by estrogen are discussed.

• Authors: V S Turusov, A B Linnik, O V Morozova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 90 Issue 11 Pg. 599-600 (Nov 1980) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Stimuliruiushchee deĭstvie éstradiola dipropionata na sarkomogenez matki, indutsiruemyĭ 1,2-dimetilgidrazinom u mysheĭ.
• PMID: 7448395 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dimethylhydrazines
• Methylhydrazines
• Estradiol

Topics

• Animals
• Cocarcinogenesis
• Dimethylhydrazines (administration & dosage)
• Estradiol (administration & dosage)
• Female
• Methylhydrazines (administration & dosage)
• Mice
• Mice, Inbred CBA
• Sarcoma, Experimental (chemically induced)
• Time Factors
• Uterine Neoplasms (chemically induced)