Antiesterase activity of chlorphenvinphos and phospholine in certain rat tissues after administration by different routes.

Abstract

The reported investigations were carried out on female Wistar rats receiving chlorphenvinphos and phospholine in doses equalling 3/4 LD50 onto the skin and intragastrically. the levels of acetylcholinesterase (AChE) were determined in the erythrocytes, liver and tibialis muscle and in three brain areas: pontomedullary area, hypothalamus and cerebral cortex. The activity of the enzyme was determined 15 and 30 minutes, and 3, 24 and 72 hours after poisoning. A high degree of AChE inhibition was observed in the brain after chlorphenvinphos poisoning (activity fall to 15--30%) and a slight decrease of AChE activity after administration of phospholine independently of the route. After oral poisoning with both preparations the AChE activity level in the erythrocytes was from about 27% to 31%, in the liver from 18 to 23%, and in the skeletal muscle from 51 to 54%, while with the transcutaneous route of poisoning these values were: 18--23%, 41--52%, and 36--48% respectively. A high degree of enzyme restoration was observed during 72 hours of observation. AChE activity was then 60--80% of the initial value.

• Authors: T Kisieliński, D Gajewski, T Gidyńska, H Owczarczyk
• Journal: Acta physiologica Polonica (Acta Physiol Pol) 1980 May-Jun Vol. 31 Issue 3 Pg. 279-88 ISSN: 0044-6033 [Print] Poland
• PMID: 7446144 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cholinesterase Inhibitors
• Insecticides
• Echothiophate Iodide
• Acetylcholinesterase
• Chlorfenvinphos

Topics

• Acetylcholinesterase (metabolism)
• Administration, Topical
• Animals
• Brain (enzymology)
• Chlorfenvinphos (administration & dosage)
• Cholinesterase Inhibitors
• Echothiophate Iodide (administration & dosage)
• Erythrocytes (enzymology)
• Female
• Insecticides (administration & dosage)
• Intubation, Gastrointestinal
• Liver (enzymology)
• Muscles (enzymology)
• Rats