The excretion of free cortisol, cortisone, cortisol sulfate and cortisone sulfate in peripheral vascular disease, diabetes mellitus and hyperthyroidism.

Abstract

In four groups of persons, 1/healthy individuals, 2/ patients with diabetes mellitus, 3/ patients with peripheral vascular disease, and 4/ patients with hyperthyroidism, the urinary excretion of free cortisol, cortisone, cortisol sulfate and cortisone sulfate was estimated. In groups 2 and 3 the excretion of all four substances was elevated. In hyperthyroidism a preponderance of free cortisone over cortisol was registered. The ratios of the followed substances suggest in patients with peripheral vascular disease a detoriation in the normal excretion of the followed corticoids, based on a preponderance of 11-OH-corticosteroids over their 11-oxo-derivatives. This observation could be implicated in the mild hyperglycemia or decreased glucose tolerance, that is often found in atherosclerotic disease.

• Authors: A Stancáková, E Merstenová, J Vajó, M Valková
• Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 10 Issue 6 Pg. 539-44 (Nov 1978) ISSN: 0018-5043 [Print] Germany
• PMID: 744572 (Publication Type: Journal Article)

Chemical References

• Cortisone
• Hydrocortisone

Topics

• Adult
• Cortisone (urine)
• Diabetes Mellitus (urine)
• Female
• Humans
• Hydrocortisone (urine)
• Hyperthyroidism (urine)
• Male
• Middle Aged
• Vascular Diseases (urine)