[Acquired coagulation inhibitors. 10 cases (author's transl)].

Abstract

A circulating anticoagulant with antiprothrombinase activity was detected in 10 patients, 4 of whom had systemic lupus erythematosus. Clinically, haemorrhages occurred only in patients with associated thrombopenia; some developed thrombosis. Recalcification time and activated partial thromboplastin time were prolonged in the patients' plasma and in mixed patients' and control plasma. In 5 cases the anticoagulant was isolated by chromatography as IgG or IgM.

• Authors: P Alexandre, E André, M E Briquel, P Labrude, F Streiff
• Journal: La Nouvelle presse medicale (Nouv Presse Med) Vol. 9 Issue 39 Pg. 2901-4 (Oct 25 1980) ISSN: 0301-1518 [Print] France
• Vernacular Title: Inhibiteurs acquis de la coagulation. 10 observations.
• PMID: 7443421 (Publication Type: English Abstract, Journal Article)

Chemical References

• Immunoglobulin G
• Immunoglobulin M

Topics

• Adolescent
• Adult
• Aged
• Anemia, Hemolytic, Autoimmune (blood)
• Blood Coagulation
• Child
• Female
• Hemostasis
• Humans
• Hypertension (blood)
• Immunoglobulin G (isolation & purification)
• Immunoglobulin M (isolation & purification)
• Lupus Erythematosus, Systemic (blood)
• Male
• Middle Aged