Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222.

Abstract

The preterminal intraperitoneal implanted rat leukemia L 5222 was used to test the chemotherapeutic activity of 10 newly synthesized nitrosoureas: ethylmethanesulfonato-CNU, acetamido-CNU, dihydroxypropyl-CNU, carboxyethyl-CNU, cyanoethyl-CNU, morpholino-CNU, piperidino-CNU, methylene-dioxybenzyl-CNU, methylene-3-pyridyl-CNU and methylene-4-pyridyl-CNU; their activity was compared against BCNU, CCNU, MeCCNU and hydroxyethyl-CNU. All compounds tested showed a more or less pronounced chemotherapeutic activity. MeCCNU was superior to all other compounds investigated. The predictive value for human tumors of results obtained from a model which is highly sensitive to nitrosoureas is discussed.

• Authors: W J Zeller, G Eisenbrand
• Journal: Oncology (Oncology) Vol. 38 Issue 1 Pg. 39-42 ( 1981) ISSN: 0030-2414 [Print] Switzerland
• PMID: 7443175 (Publication Type: Journal Article)

Chemical References

• Nitrosourea Compounds
• 1-(2-chloroethyl)-1-nitrosourea
• Ethylnitrosourea

Topics

• Animals
• Dose-Response Relationship, Drug
• Ethylnitrosourea (analogs & derivatives, therapeutic use)
• Female
• Leukemia, Experimental (drug therapy)
• Male
• Nitrosourea Compounds (therapeutic use)
• Rats
• Rats, Inbred Strains
• Structure-Activity Relationship