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Bile salt transport in the Dubin-Johnson syndrome.

Abstract
Serum bile salt measurements and intravenous clearance of glycocholate were performed in a woman with Dubin-Johnson syndrome. Fasting conjugated cholate concentration was raised and prolonged intravenous clearance of sodium glycocholate revealed a secondary rise in conjugated cholate concentration after two hours. The intravenous clearance of bromsulphthalein also showed a secondary rise. These findings support the proposal that Dubin-Johnson syndrome is not homogeneous and that in some patients a abnormality of bile salt clearance coexists with an abnormality of bilirubin nd bromsulphthalein clearance.
AuthorsJ G Douglas, G J Beckett, I W Percy-Robb, N D Finlayson
JournalGut (Gut) Vol. 21 Issue 10 Pg. 890-3 (Oct 1980) ISSN: 0017-5749 [Print] England
PMID7439808 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholic Acids
  • Sulfobromophthalein
  • Glycocholic Acid
Topics
  • Aged
  • Cholic Acids (blood)
  • Female
  • Glycocholic Acid
  • Humans
  • Jaundice, Chronic Idiopathic (blood)
  • Metabolic Clearance Rate
  • Middle Aged
  • Sulfobromophthalein

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