Abstract |
Serum bile salt measurements and intravenous clearance of glycocholate were performed in a woman with Dubin-Johnson syndrome. Fasting conjugated cholate concentration was raised and prolonged intravenous clearance of sodium glycocholate revealed a secondary rise in conjugated cholate concentration after two hours. The intravenous clearance of bromsulphthalein also showed a secondary rise. These findings support the proposal that Dubin-Johnson syndrome is not homogeneous and that in some patients a abnormality of bile salt clearance coexists with an abnormality of bilirubin nd bromsulphthalein clearance.
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Authors | J G Douglas, G J Beckett, I W Percy-Robb, N D Finlayson |
Journal | Gut
(Gut)
Vol. 21
Issue 10
Pg. 890-3
(Oct 1980)
ISSN: 0017-5749 [Print] England |
PMID | 7439808
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholic Acids
- Sulfobromophthalein
- Glycocholic Acid
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Topics |
- Aged
- Cholic Acids
(blood)
- Female
- Glycocholic Acid
- Humans
- Jaundice, Chronic Idiopathic
(blood)
- Metabolic Clearance Rate
- Middle Aged
- Sulfobromophthalein
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