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Lack of delayed reaction in presence of cell-mediated immunity in trichophytin hypersensitivity.

Abstract
Five patients with atopy who had chronic dermatophytosis manifested an immediate and strong trichophytin skin reaction but no delayed reaction. This phenomenon may be caused by the neutralization of injected antigen by serum antibodies during the immediate reaction. When we injected a second dose of trichophytin into the wheal of the immediate reaction, 20 minutes after the first injection, a strong delayed reaction was elicited, demonstrating cell-mediated immune responses in these patients.
AuthorsN Hunziker, R Brun
JournalArchives of dermatology (Arch Dermatol) Vol. 116 Issue 11 Pg. 1266-8 (Nov 1980) ISSN: 0003-987X [Print] United States
PMID7436432 (Publication Type: Journal Article)
Chemical References
  • Trichophytin
Topics
  • Adolescent
  • Adult
  • Chronic Disease
  • Female
  • Humans
  • Hypersensitivity, Delayed (immunology)
  • Immunity, Cellular
  • Male
  • Tinea (immunology)
  • Trichophytin (immunology)

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