Differentiation of various experimentally-induced patholgical processes in Wistar rats by serum protein electrophoresis using cellulose-acetate membranes.

Abstract

Plasma protein profiles were investigated electrophoretically in rats with aminonucleoside-induced glomerular damage, uranyl-nitrate-induced tubular damage, phalloidin-induced hepatocyte membrane damage, adjuvant arthritis as a model of chronic inflammation, and phenyl isothiocyanate pleurisy as a model of acute inflammation. Characteristic profiles were observed for each experimental disease, and their development and seriousness could be evaluated. Similar studies are already routinely used in clinical investigations of human plasma.

• Authors: M Rothkopf-Ischebeck
• Journal: Laboratory animals (Lab Anim) Vol. 14 Issue 2 Pg. 153-65 (Apr 1980) ISSN: 0023-6772 [Print] England
• PMID: 7431826 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Blood Proteins
• Isothiocyanates
• Thiocyanates
• Uranyl Nitrate
• phenylisothiocyanate
• Phalloidine
• Puromycin Aminonucleoside

Topics

• Animals
• Blood Proteins (analysis)
• Chemical and Drug Induced Liver Injury
• Electrophoresis, Cellulose Acetate
• Isothiocyanates
• Kidney Diseases (blood, chemically induced, veterinary)
• Liver Diseases (blood, veterinary)
• Phalloidine
• Pleurisy (blood, chemically induced, veterinary)
• Puromycin Aminonucleoside
• Rats
• Rodent Diseases (blood, chemically induced)
• Thiocyanates
• Uranyl Nitrate