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Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal.

Abstract
A combination of indomethacin and diflunisal, a new salicylic acid derivative, when given to rats, gave a greater reduction in the size of permanganate induced granulomas and less gastric irritation, than either drug given alone.
AuthorsP Conti, A Continenza
JournalThe Journal of pathology (J Pathol) Vol. 131 Issue 4 Pg. 357-61 (Aug 1980) ISSN: 0022-3417 [Print] England
PMID7431153 (Publication Type: Journal Article)
Chemical References
  • Salicylates
  • Diflunisal
  • Indomethacin
Topics
  • Animals
  • Diflunisal (administration & dosage, toxicity)
  • Drug Therapy, Combination
  • Granuloma (drug therapy)
  • Indomethacin (administration & dosage, toxicity)
  • Male
  • Rats
  • Salicylates (toxicity)
  • Stomach Diseases (drug therapy)
  • Stomach Ulcer (chemically induced)

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