Myocardial imaging and metabolic studies with [17-123I]iodoheptadecanoic acid.

Abstract

After intravenous administration of the stearic acid analogue [17-123I]iodoheptadecanoic acid (I-123 HA), myocardial metabolism was studied in ten normal individuals, eight patients with coronary artery disease and three patients with congestive heart failure. High-quality images were obtained in sequential scintigraphy of I-123 metabolically bound in myocardial tissue. Infarcted zones as well as ischemic regions are indicated by reduced tracer uptake. Iodine-123 in the blood pool and interstitial space consists mainly of radioiodide that is liberated by fatty-acid metabolism and was corrected for. Using the proposed correction not only are the images improved but the uptake and elimination of the I-123 in the myocardial cells can be followed. The average disappearance half-time of I-123 HA from the myocardium of normal persons was 24 +/- 4.7 min. In patients with coronary artery disease significant differences between myocardial regions were observed.

• Authors: C Freundlieb, A Höck, K Vyska, L E Feinendegen, H J Machulla, G Stöcklin
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 21 Issue 11 Pg. 1043-50 (Nov 1980) ISSN: 0161-5505 [Print] United States
• PMID: 7431103 (Publication Type: Journal Article)

Chemical References

• Fatty Acids
• Fatty Acids, Nonesterified
• Iodine Radioisotopes
• 17-iodoheptadecanoic acid

Topics

• Adult
• Aged
• Coronary Disease (diagnostic imaging)
• Fatty Acids
• Fatty Acids, Nonesterified (metabolism)
• Half-Life
• Heart (diagnostic imaging)
• Heart Diseases (blood, diagnostic imaging, metabolism)
• Heart Failure (diagnostic imaging)
• Humans
• Iodine Radioisotopes
• Male
• Middle Aged
• Myocardium (metabolism)
• Radionuclide Imaging