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Evaluation of iron-chelating agents in cultured heart muscle cells. Identification of a potential drug for chelation therapy.

Abstract
Primary cultures of neonatal rat cardiac muscle cells incorporated radioiron from both [55Fe]transferrin and 59FeCl3 (added simultaneously). To evaluate the effect of iron chelators on such uptake, deferri chelators were added 6 hr after addition of the radioiron sources. The microbial chelator agrobactin was significantly more effective than the drug defoxamine in reduction of 55Fe uptake from [55Fe]transferrin; both chelators halted 59Fe3+ uptake. Agrobactin may have potential in chelation therpay for iron-overload disease. Certain other microbial chelators lowered radioiron uptake from either [55Fe]transferrin of 59FeCl3. These chelators should be useful inhibitors for studies of animal cell iron uptake and intracellular iron flow.
AuthorsC V Sciortino, B R Byers, P Cox
JournalThe Journal of laboratory and clinical medicine (J Lab Clin Med) Vol. 96 Issue 6 Pg. 1081-5 (Dec 1980) ISSN: 0022-2143 [Print] United States
PMID7430764 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Iron Chelating Agents
  • Iron Radioisotopes
  • Deferoxamine
Topics
  • Animals
  • Deferoxamine (therapeutic use)
  • Iron Chelating Agents (therapeutic use)
  • Iron Radioisotopes (metabolism)
  • Myocardium (metabolism)
  • Rats

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