Abstract |
Acyclovir, a new potent antiviral drug, was used to treat herpes simplex virus (HSV) infection in the rabbit ocular model. Acyclovir (3% ointment) used topically one to five times a day on acute ocular HSV infection gave beneficial results as measured by a reduction in corneal involvement, conjunctivitis, iritis, and corneal clouding. Topical treatment did not prevent the establishment of latent HSV infection. Intravenous acyclovir used two times a day (50 mg/kg) on rabbits with latent HSV infection appeared to suppress HSV in the nervous system but did not eradicate established latent HSV infection.
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Authors | M D Trousdale, E C Dunkel, A B Nesburn |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 19
Issue 11
Pg. 1336-41
(Nov 1980)
ISSN: 0146-0404 [Print] United States |
PMID | 7429768
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antiviral Agents
- Guanine
- Acyclovir
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Topics |
- Acyclovir
- Administration, Topical
- Animals
- Antiviral Agents
(therapeutic use)
- Disease Models, Animal
- Guanine
(analogs & derivatives, therapeutic use)
- Injections, Intravenous
- Keratitis, Dendritic
(drug therapy)
- Male
- Rabbits
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