The sustained antihypertensive effect of chronic cerebroventricular infusion of angiotensin antagonist in spontaneously hypertensive rats.

Abstract

The angiotensin antagonist [Sar1-Ile8]angiotensin II was infused into the lateral ventricles of mature spontaneously hypertensive and normotensive Wistar-Kyoto rats. Infusions were maintained at rats of 1200 ng/h for 6 days, and blood pressure was measured daily in the unanesthetized state. Blood pressure reduction occurred promptly and only in the hypertensive animals. This antihypertensive effect persisted for several days after discontinuation of the infusion. In contrast, iv infusion of the angiotensin antagonist at comparable doses failed to alter blood pressure in any significant fashion. These data suggest that the brain isorenin system participates in the maintenance of hypertension in the spontaneously hypertensive rat.

• Authors: W McDonald, C Wickre, S Aumann, D Ban, B Moffitt
• Journal: Endocrinology (Endocrinology) Vol. 107 Issue 5 Pg. 1305-8 (Nov 1980) ISSN: 0013-7227 [Print] United States
• PMID: 7428673 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Angiotensin II
• 1-Sarcosine-8-Isoleucine Angiotensin II

Topics

• 1-Sarcosine-8-Isoleucine Angiotensin II (administration & dosage, therapeutic use)
• Angiotensin II (analogs & derivatives)
• Animals
• Blood Pressure (drug effects)
• Cerebral Ventricles
• Hypertension (drug therapy)
• Infusions, Parenteral
• Kinetics
• Male
• Rats