Effect of conjugated and unconjugated hyperbilirubinaemia on the plasma 25-hydroxy-vitamin D response to ultraviolet radiation in the rat.

Abstract

1. Vitamin D deficiency was induced in anicteric Wistar rats, Wistar rats before common bile-duct ligation was performed and Gunn rats with unconjugated hyperbilirubinaemia. 2. The effect of ultraviolet radiation on plasma concentrations of 25-hydroxy-vitamin D was studied in a group of control anicteric Wistar rats (n = 11), Wistar rats 8 days after common bile-duct ligation (n = 7) with conjugated hyperbilirubinaemia and in Gunn rats (n = 11). 3. The plasma 25-hydroxy-vitamin D response to ultraviolet radiation was similar in the three groups. 4. It is suggested that neither conjugated nor unconjugated hyperbilirubinaemia prevent cutaneous vitamin D3 synthesis or 25-hydroxylation in the rat.

• Authors: R G Long, J M Barragry, P Mitchenere, M S Beer, B J Boucher, R D Cohen
• Journal: Clinical science (London, England : 1979) (Clin Sci (Lond)) Vol. 59 Issue 4 Pg. 293-6 (Oct 1980) ISSN: 0143-5221 [Print] England
• PMID: 7428297 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydroxycholecalciferols

Topics

• Animals
• Hydroxycholecalciferols (blood)
• Hyperbilirubinemia (blood)
• Male
• Radiation Effects
• Rats
• Ultraviolet Rays
• Vitamin D Deficiency (blood)