Inhibition of calcium oxalate crystal growth in urine during treatment with allopurinol.

Abstract

Twelve male patients with urolithiasis were treated with 300 mg allopurinol daily. Urinary urate decreased from 251 +/- 55 to 156 +/- 19 (mean +/- SD) mmol per mol creatinine. The inhibition of calcium oxalate crystal growth was measured in an in vitro system and the inhibition index increased from 0.51 +/- 0.06 to 0.57 +/- 0.08 (mean +/- SD). Urinary citrate excretion was unaffected by the treatment.

• Authors: H G Tiselius
• Journal: British journal of urology (Br J Urol) Vol. 52 Issue 3 Pg. 189-92 (Jun 1980) ISSN: 0007-1331 [Print] England
• PMID: 7426978 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Oxalate
• Uric Acid
• Allopurinol

Topics

• Allopurinol (therapeutic use)
• Calcium Oxalate (urine)
• Crystallization
• Humans
• Male
• Uric Acid (urine)
• Urinary Calculi (drug therapy, urine)