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Perioral leukoderma simulating vitiligo from use of a toothpaste containing cinnamic aldehyde.

Abstract
Perioral leukoderma simulating vitiligo developed in a 25-year-old woman. A patch test to cinnamic aldehyde was positive; depigmentation was observed at the patch test site three months after initial application. No changes in pigmentation occurred from a concomitant allergic patch test reaction to neomycin sulfate; only hyperpigmentation occurred at the site of an irritant patch test reaction to nonanoic acid. A toothpaste containing cinnamic aldehyde was implicated; perioral hypopigmentation resolved when a toothpaste without cinnamic aldehyde was substituted. A repeated patch test to cinnamic aldehyde again showed depigmentation at the patch test site three months after application.
AuthorsC G Mathias, H I Maibach, M A Conant
JournalArchives of dermatology (Arch Dermatol) Vol. 116 Issue 10 Pg. 1172-3 (Oct 1980) ISSN: 0003-987X [Print] United States
PMID7425664 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Aldehydes
  • Dentifrices
  • Toothpastes
  • Acrolein
  • cinnamaldehyde
Topics
  • Acrolein (adverse effects, analogs & derivatives)
  • Adult
  • Aldehydes (adverse effects)
  • Dentifrices (adverse effects)
  • Diagnosis, Differential
  • Facial Dermatoses (chemically induced)
  • Female
  • Humans
  • Patch Tests
  • Pigmentation Disorders (chemically induced, diagnosis)
  • Toothpastes (adverse effects)
  • Vitiligo (diagnosis)

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