[Ototoxicity of locally applied amino-glycosides (author's transl)].

Abstract

Medical literature contains numerous references to the ototoxic effects of amino-glycosides if locally applied. In the present study patients who had fallen ill with otitis externa with concomitant myringitis, whose eardrum however, was intact, were treated with Neomycin and Polymyxin B containing ear-drops (Otosporin) and supervised audiometrically. There were no references to any ototoxic damage to the inner ear as a consequence of the treatment. Theoretical considerations and reports in the literature on the subject give advice to caution in the case of eardrum perforations and surgical caverns.

• Authors: M Arnoldner
• Journal: Wiener medizinische Wochenschrift (1946) (Wien Med Wochenschr) Vol. 130 Issue 13-14 Pg. 486-8 (Jul 31 1980) ISSN: 0043-5341 [Print] Austria
• Vernacular Title: Uber due Ototoxizität von Aminoglykosiden bei lokaler Anwendung.
• PMID: 7424038 (Publication Type: Journal Article)

Chemical References

• Aminoglycosides
• Neomycin

Topics

• Aminoglycosides (adverse effects)
• Ear, Inner (drug effects)
• Hearing Tests
• Humans
• Neomycin (therapeutic use)
• Otitis Externa (drug therapy)