Ultrastructural changes in gastric ulcers after bicitropeptide and cimetidine treatment.

Abstract

Ultrastructural studies were conducted on biopsy specimens taken by endoscopy from the edge of gastric ulcers in the distal part of the stomach of 9 patients before and after treatment with either bicitropeptide or cimetidine. Marked depletion of mucin granules in the mucous epithelial cells and the pyloric gland cells was found in all patients and there was morphological evidence of a block in the synthesis of mucus glycoproteins. This block was located in the Golgi region of these cells. Synthesis of structurally normal mucin granules was restored after treatment with either bicitropeptide or cimetidine.

• Authors: J J Theron, R C Mekel
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 58 Issue 16 Pg. 634-8 (Oct 18 1980) ISSN: 0256-9574 [Print] South Africa
• PMID: 7423308 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• Guanidines
• Metalloproteins
• Proteins
• bicitropeptide
• Cimetidine
• Bismuth

Topics

• Adult
• Anti-Ulcer Agents (pharmacology, therapeutic use)
• Bismuth (pharmacology)
• Cimetidine (pharmacology, therapeutic use)
• Female
• Guanidines (pharmacology)
• Humans
• Male
• Metalloproteins
• Microscopy, Electron
• Middle Aged
• Proteins (pharmacology)
• Stomach Ulcer (drug therapy, pathology)
• Time Factors