HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Assessment of photomirex toxicity in the mouse.

Abstract
Toxicity in the mouse was produced after oral administration of photomirex at 10, 25 and 50 mg/kg.d in corn oil. Mortality began to occur 4, 7, and 16 d after daily administration of photomirex at 50, 25, and 20 mg/kg, respectively. In all cases, the cumulative LD50 for photomirex was estimated as 225-250 mg/kg. The effect of photomirex on food and water consumption varied depending on dose. Daily oral administration of photomirex caused a dose-dependent loss of body weight. No overt behavioral changes were observed during the experiments. Body temperature was unaffected. Biochemical studies also showed that photomirex did not affect plasma glucose and free fatty acid content and brain biogenic amine levels. It appears that photomirex is similar to mirex in terms of peripheral toxicity.
AuthorsK Fujimori, I K Ho, H M Mehendale
JournalJournal of toxicology and environmental health (J Toxicol Environ Health) Vol. 6 Issue 4 Pg. 869-76 (Jul 1980) ISSN: 0098-4108 [Print] United States
PMID7420486 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amines
  • Blood Glucose
  • Fatty Acids
  • Insecticides
  • photomirex
  • Mirex
Topics
  • Amines (analysis)
  • Animals
  • Blood Glucose
  • Body Temperature (drug effects)
  • Body Weight (drug effects)
  • Brain Chemistry
  • Eating (drug effects)
  • Fatty Acids (blood)
  • Insecticides (toxicity)
  • Lethal Dose 50
  • Male
  • Mice
  • Mice, Inbred ICR
  • Mirex (analogs & derivatives, toxicity)
  • Mortality

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: