[Dimethyl-triazeno-imidazole-carboxamide (DTIC) in combination chemotherapy for childhood neuroblastoma (author's transl)].

Abstract

Eight children with state III or IV neuroblastoma were treated with courses of chemotherapy consisting of nitrogen mustard (6 mg/m2), vincristine (2 X 1.5 mg/m2), doxorubicin (40 mg/m2) and dimethyl-triazeno-imidazolecarboxamide (850 mg/m2) every three weeks. Three children died after a median survival of 8 (+/-5) months. Five children (62%) have now survived for a medium duration of 21 (+/-16) months without clinical evidence of disease. These results are far better than previously-achieved survival rates at our department.

• Authors: I D Mutz, C E Urban
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 90 Issue 24 Pg. 867-70 (Dec 22 1978) ISSN: 0043-5325 [Print] Austria
• Vernacular Title: Chemotherapie bei Neuroblastom im Kindesalter mit einer Dimethyl-Triazeno-Imidazol-Carboxamid-(DTIC-)Kombination.
• PMID: 741754 (Publication Type: English Abstract, Journal Article)

Chemical References

• Triazenes
• Mechlorethamine
• Vincristine
• Dacarbazine
• Doxorubicin

Topics

• Child, Preschool
• Dacarbazine (administration & dosage, therapeutic use)
• Doxorubicin (administration & dosage, therapeutic use)
• Drug Evaluation
• Drug Therapy, Combination
• Female
• Humans
• Infant
• Male
• Mechlorethamine (administration & dosage, therapeutic use)
• Neuroblastoma (drug therapy, mortality)
• Triazenes (therapeutic use)
• Vincristine (administration & dosage, therapeutic use)