[Toxicity of the pesticide nabam as a function of dietary protein content in the rat].

Abstract

With the object of studying a possible toxical potentialization between a food pollutent and the diet compoundings, rats fed on a diet with variable protein amounts, were administered a pesticide belonging to the Dithiocarbamate family : Nabam. Animals have been fed for 28 days after they have been weaned with diets containing 0-3.5 - 9 - 26 and 81% proteins in casein form. DL50 is significantly lowered in rats fed 0 - 3,5 and 81% protein diets compared with DL50 estimations in rats normally fed. Toxical clinical signs are fundamentally the same ones in all rats of the six groups : stimulation followed by a depression of the central nervous system, severe inflammation of the gastro-intestinal tractus, significant renal necroses. The intertime between poisoning and death seems not to be influenced by the diet protein amounts and is only due to the Nabam dose.

• Authors: A Periquet, R Derache
• Journal: Toxicological European research. Recherche europeenne en toxicologie (Toxicol Eur Res) Vol. 1 Issue 1 Pg. 27-37 (Jan 1978) ISSN: 0249-6402 [Print] France
• Vernacular Title: Toxicité d'un pesticide, le nabame, en fonction du taux protéique alimentaire chez le rat.
• PMID: 741467 (Publication Type: Journal Article)

Chemical References

• Dietary Proteins
• Ethylenebis(dithiocarbamates)
• Fungicides, Industrial
• Herbicides
• Thiocarbamates
• nabam

Topics

• Animals
• Body Weight (drug effects)
• Dietary Proteins (pharmacology)
• Ethylenebis(dithiocarbamates) (toxicity)
• Fungicides, Industrial (toxicity)
• Herbicides (toxicity)
• Lethal Dose 50
• Male
• Organ Size (drug effects)
• Rats
• Thiocarbamates (toxicity)
• Time Factors